BBS9 [The Human Chemical-Genetic Interaction Map Project]

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======= BBS9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BBS9
  * **<color #00a2e8>Official Name</color>**: Bardet-Biedl syndrome 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27241|27241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3SYG4|Q3SYG4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BBS9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BBS9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607968|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is downregulated by parathyroid hormone in osteoblastic cells, and therefore is thought to be involved in parathyroid hormone action in bones. The exact function of this gene has not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BBSome|
|pericentriolar material|
|ciliary transition zone|
|centriolar satellite|
|protein localization to cilium|
|ciliary membrane|
|fat cell differentiation|
|cilium|
|visual perception|
|sensory perception of light stimulus|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|protein localization to organelle|
|organelle assembly|
|molecular function|
|sensory perception|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|nervous system process|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|nitrogen compound transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.33|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.31|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.95|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.92|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.9|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.89|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.87|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.84|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.76|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.76|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.73|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.76|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.78|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.79|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.86|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.86|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.89|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.2|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.29|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.33|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10647
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BBS9 Expression in NALM6 Cells: 3.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>