BBS9

Entrez Summary: This gene is downregulated by parathyroid hormone in osteoblastic cells, and therefore is thought to be involved in parathyroid hormone action in bones. The exact function of this gene has not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-2.33
Pyronaridine 1μM R06 exp295	-2.31
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.95
MSC2530818 10μM R07 exp379	-1.92
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.9
Beta-Estradiol 0.55μM R07 exp425	-1.89
Calcium Ionophore 0.4μM R07 exp342	-1.87
THZ531 0.225μM R08 exp444	-1.84
Cabazitaxel 0.001μM R05 exp223	-1.76
Wortmannin 0.5μM R00 exp37	-1.76
UM131593 0.2μM R03 exp106	1.73
R-DABN 8μM R03 exp111	1.76
Resveratrol 16μM R03 exp147	1.78
DABN racemic mixture R03 exp93	1.79
Nifuroxazide 1μM R01 exp51	1.86
Rotenone 2μM R00 exp33	1.86
Zebularine 20μM R07 exp423	1.89
CyclicAMP 200μM R08 exp475	2.2
Nocodazole 0.2μM R00 exp24	2.29
Vinblastine 0.015μM R05 exp208	2.33
Nocodazole 0.1μM R03 exp94	3.1

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

BBSome
pericentriolar material
ciliary transition zone
centriolar satellite
protein localization to cilium
ciliary membrane
fat cell differentiation
cilium
visual perception
sensory perception of light stimulus
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
protein localization to organelle
organelle assembly
molecular function
sensory perception
plasma membrane bounded cell projection organization
cell projection organization
nervous system process
protein transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
nitrogen compound transport
system process
membrane