BCHE [The Human Chemical-Genetic Interaction Map Project]

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======= BCHE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCHE
  * **<color #00a2e8>Official Name</color>**: butyrylcholinesterase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=590|590]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06276|P06276]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCHE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCHE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/177400|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. {ECO:0000269|PubMed:19452557, ECO:0000269|PubMed:19542320}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AChE tetra|
|Abhydrolase 3|
|COesterase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cocaine metabolic process|
|tropane alkaloid metabolic process|
|acetylcholinesterase activity|
|cholinesterase activity|
|neuroblast differentiation|
|choline binding|
|alkaloid metabolic process|
|choline metabolic process|
|nuclear envelope lumen|
|response to folic acid|
|catalytic activity|
|negative regulation of synaptic transmission|
|amyloid-beta binding|
|response to vitamin|
|neurotransmitter metabolic process|
|response to alkaloid|
|xenobiotic metabolic process|
|blood microparticle|
|response to glucocorticoid|
|learning|
|stem cell differentiation|
|response to corticosteroid|
|cellular response to xenobiotic stimulus|
|ammonium ion metabolic process|
|response to nutrient|
|learning or memory|
|cognition|
|response to xenobiotic stimulus|
|endoplasmic reticulum lumen|
|response to steroid hormone|
|response to acid chemical|
|enzyme binding|
|regulation of neurotransmitter levels|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|response to nutrient levels|
|drug metabolic process|
|response to extracellular stimulus|
|behavior|
|negative regulation of cell population proliferation|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|identical protein binding|
|response to nitrogen compound|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|neurogenesis|
|extracellular region|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.75|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13996
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCHE Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>