BCHE

Entrez Summary: This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016].
UniProt Summary: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. {ECO:0000269|PubMed:19452557, ECO:0000269|PubMed:19542320}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.75
Pifithrin-alpha 20μM R07 exp390	1.89

cocaine metabolic process
tropane alkaloid metabolic process
acetylcholinesterase activity
cholinesterase activity
neuroblast differentiation
choline binding
alkaloid metabolic process
choline metabolic process
nuclear envelope lumen
response to folic acid
catalytic activity
negative regulation of synaptic transmission
amyloid-beta binding
response to vitamin
neurotransmitter metabolic process
response to alkaloid
xenobiotic metabolic process
blood microparticle
response to glucocorticoid
learning
stem cell differentiation
response to corticosteroid
cellular response to xenobiotic stimulus
ammonium ion metabolic process
response to nutrient
learning or memory
cognition
response to xenobiotic stimulus
endoplasmic reticulum lumen
response to steroid hormone
response to acid chemical
enzyme binding
regulation of neurotransmitter levels
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
response to nutrient levels
drug metabolic process
response to extracellular stimulus
behavior
negative regulation of cell population proliferation