BCL10

Entrez Summary: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
UniProt Summary: Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101). {ECO:0000269|PubMed:18264101, ECO:0000269|PubMed:25365219}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

interleukin-6 biosynthetic process
lymphotoxin A production
lymphotoxin A biosynthetic process
positive regulation of mast cell cytokine production
regulation of mature B cell apoptotic process
CBM complex
negative regulation of mature B cell apoptotic process
regulation of mast cell cytokine production
kinase activator activity
B cell apoptotic process
tumor necrosis factor superfamily cytokine production
negative regulation of B cell apoptotic process
interleukin-6 production
protein kinase B binding
positive regulation of interleukin-8 biosynthetic process
cytokine biosynthetic process
T cell apoptotic process
cytokine metabolic process
regulation of interleukin-8 biosynthetic process
CARD domain binding
regulation of B cell apoptotic process
lymphocyte apoptotic process
positive regulation of myeloid leukocyte cytokine production involved in immune response
response to food
leukocyte apoptotic process
negative regulation of lymphocyte apoptotic process
NF-kappaB binding
lipopolysaccharide-mediated signaling pathway
immunological synapse
regulation of T cell receptor signaling pathway
negative regulation of leukocyte apoptotic process
positive regulation of interleukin-8 production
response to fungus
positive regulation of extrinsic apoptotic signaling pathway
regulation of lymphocyte apoptotic process
cytoplasmic microtubule
cellular defense response
positive regulation of cytokine production involved in immune response
protein self-association
regulation of antigen receptor-mediated signaling pathway