BCL11A [The Human Chemical-Genetic Interaction Map Project]

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======= BCL11A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCL11A
  * **<color #00a2e8>Official Name</color>**: BAF chromatin remodeling complex subunit BCL11A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53335|53335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H165|Q9H165]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCL11A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCL11A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606557|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of neuron remodeling|
|negative regulation of neuron remodeling|
|negative regulation of branching morphogenesis of a nerve|
|negative regulation of dendrite extension|
|negative regulation of neuron maturation|
|regulation of branching morphogenesis of a nerve|
|cellular response to L-glutamate|
|negative regulation of cell maturation|
|regulation of neuron maturation|
|response to L-glutamate|
|regulation of cell maturation|
|regulation of dendrite extension|
|negative regulation of dendrite development|
|regulation of morphogenesis of a branching structure|
|protein sumoylation|
|cellular response to nutrient|
|cellular response to amino acid stimulus|
|negative regulation of developmental growth|
|response to amino acid|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|cellular response to acid chemical|
|response to nutrient|
|negative regulation of neuron differentiation|
|cellular response to nutrient levels|
|negative regulation of growth|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|postsynaptic density|
|cellular response to extracellular stimulus|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|peptidyl-lysine modification|
|regulation of developmental growth|
|negative regulation of cell development|
|cellular response to external stimulus|
|response to acid chemical|
|cellular response to drug|
|regulation of cell growth|
|sequence-specific DNA binding|
|protein kinase binding|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to extracellular stimulus|
|cellular response to organonitrogen compound|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|DNA-binding transcription factor activity|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|negative regulation of gene expression|
|regulation of cell differentiation|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.28|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-3.26|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.68|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.63|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.28|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.2|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.13|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.99|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.89|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.87|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.87|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.83|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.8|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.8|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.76|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.72|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.89|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|2.02|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.02|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.04|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.06|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.11|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.19|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.26|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.28|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.31|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16749
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCL11A Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>