BCL11A

Entrez Summary: This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 5ng/ml R00 exp35	-3.28
TRAIL 50ng/ml R00 exp36	-3.26
Lead acetate 2000μM R08 exp497	-2.68
Lead acetate 2000μM R08 exp498 no dilution day6	-2.63
Taxol 0.004μM R03 exp103	-2.28
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.2
Salubrinal 20μM R07 exp399	-2.13
ML-792 0.2μM R08 exp505	-1.99
Epothilone-B 0.0015μM R05 exp231	-1.89
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.87
UM131593 0.2μM R03 exp106	-1.87
Trichostatin-A 0.06μM R07 exp415	-1.83
Bortezomib 0.05μM R00 exp7	-1.8
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.8
HMS-I2 10μM R06 exp288	-1.76
FK-506 30μM R07 exp359	-1.73
Arsenate 40μM R06 exp264	-1.72
Vincristine 0.0005μM R04 exp190	1.89
Aphidicolin 0.04μM R06 exp263	2.02
BH1 1μM R04 exp169	2.02
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.04
LY2090314 0.003μM R08 exp499	2.06
Thapsigargin 0.005μM R07 exp407	2.11
Bafilomycin-A1 0.009μM R08 exp454	2.19
Vemurafenib 6.6μM R08 exp434	2.26
Losmapimod 1μM R07 exp376	2.28
Cryptotanshinone 12μM R05 exp227	2.31
ABT-702 5μM plus CoCl2 18μM R07 exp320	2.39

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of neuron remodeling
negative regulation of neuron remodeling
negative regulation of branching morphogenesis of a nerve
negative regulation of dendrite extension
negative regulation of neuron maturation
regulation of branching morphogenesis of a nerve
cellular response to L-glutamate
negative regulation of cell maturation
regulation of neuron maturation
response to L-glutamate
regulation of cell maturation
regulation of dendrite extension
negative regulation of dendrite development
regulation of morphogenesis of a branching structure
protein sumoylation
cellular response to nutrient
cellular response to amino acid stimulus
negative regulation of developmental growth
response to amino acid
regulation of dendrite development
negative regulation of neuron projection development
negative regulation of cell projection organization
negative regulation of cell growth
cellular response to acid chemical
response to nutrient
negative regulation of neuron differentiation
cellular response to nutrient levels
negative regulation of growth
DNA-binding transcription repressor activity, RNA polymerase II-specific
postsynaptic density
cellular response to extracellular stimulus
negative regulation of neurogenesis
negative regulation of nervous system development
peptidyl-lysine modification
regulation of developmental growth
negative regulation of cell development
cellular response to external stimulus
response to acid chemical
cellular response to drug
regulation of cell growth