BCL2L10

Gene Information

Official Symbol: BCL2L10
Official Name: BCL2 like 10
Aliases and Previous Symbols: N/A
Entrez ID: 10017
UniProt: Q9HD36
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. {ECO:0000269|PubMed:11278245}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6634
Expression level (log2 read counts): -3.13

Expression Distribution

caspase binding
signal transduction in absence of ligand
extrinsic apoptotic signaling pathway in absence of ligand
intrinsic apoptotic signaling pathway in response to DNA damage
activation of cysteine-type endopeptidase activity involved in apoptotic process
extrinsic apoptotic signaling pathway
female gamete generation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
intrinsic apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity
mitochondrial outer membrane
positive regulation of endopeptidase activity
positive regulation of peptidase activity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
nuclear membrane
regulation of cysteine-type endopeptidase activity
apoptotic signaling pathway
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
protein heterodimerization activity
spermatogenesis
male gamete generation
positive regulation of apoptotic process
positive regulation of programmed cell death
gamete generation
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
cellular response to DNA damage stimulus
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
protein homodimerization activity
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
multi-organism reproductive process
negative regulation of cell death
programmed cell death