BCL9L

Gene Information

Official Symbol: BCL9L
Official Name: BCL9 like
Aliases and Previous Symbols: N/A
Entrez ID: 283149
UniProt: Q86UU0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4471
Expression level (log2 read counts): 4.05

Expression Distribution

beta-catenin-TCF complex
beta-catenin-TCF complex assembly
positive regulation of epithelial to mesenchymal transition
skeletal muscle cell differentiation
somatic stem cell population maintenance
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
regulation of epithelial to mesenchymal transition
beta-catenin binding
canonical Wnt signaling pathway
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
skeletal muscle tissue development
skeletal muscle organ development
stem cell population maintenance
maintenance of cell number
negative regulation of cellular response to growth factor stimulus
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
striated muscle tissue development
transcription coactivator activity
muscle organ development
muscle tissue development
Wnt signaling pathway
cell-cell signaling by wnt
cell surface receptor signaling pathway involved in cell-cell signaling
muscle structure development
regulation of cell morphogenesis
nucleolus
positive regulation of cell differentiation
regulation of anatomical structure morphogenesis
cell-cell signaling
positive regulation of transcription by RNA polymerase II
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of developmental process
positive regulation of transcription, DNA-templated
protein-containing complex assembly