BDKRB2 [The Human Chemical-Genetic Interaction Map Project]

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======= BDKRB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BDKRB2
  * **<color #00a2e8>Official Name</color>**: bradykinin receptor B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=624|624]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30411|P30411]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BDKRB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BDKRB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/113503|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|
|bradykinin receptor activity|
|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|
|regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|
|type 1 angiotensin receptor binding|
|regulation of cellular response to osmotic stress|
|regulation of response to osmotic stress|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|response to salt stress|
|arachidonic acid secretion|
|arachidonate transport|
|negative regulation of peptidyl-serine phosphorylation|
|phosphatidylinositol phospholipase C activity|
|icosanoid secretion|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|vasodilation|
|fatty acid derivative transport|
|vasoconstriction|
|icosanoid transport|
|negative regulation of signal transduction by p53 class mediator|
|regulation of vascular permeability|
|negative regulation of blood vessel diameter|
|smooth muscle contraction|
|regulation of vasoconstriction|
|positive regulation of blood vessel diameter|
|long-chain fatty acid transport|
|fatty acid transport|
|response to osmotic stress|
|acid secretion|
|negative regulation of intrinsic apoptotic signaling pathway|
|protease binding|
|monocarboxylic acid transport|
|regulation of peptidyl-serine phosphorylation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|regulation of intrinsic apoptotic signaling pathway|
|vascular process in circulatory system|
|regulation of signal transduction by p53 class mediator|
|negative regulation of apoptotic signaling pathway|
|muscle contraction|
|endosome|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|muscle system process|
|lipid localization|
|regulation of cytosolic calcium ion concentration|
|blood circulation|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|cellular calcium ion homeostasis|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|organic anion transport|
|cellular divalent inorganic cation homeostasis|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|inflammatory response|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|anion transport|
|regulation of system process|
|negative regulation of protein modification process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|ion homeostasis|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|secretion|
|response to abiotic stimulus|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of cell death|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12342
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BDKRB2 Expression in NALM6 Cells: -0.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>