BDKRB2
Gene Information
- Official Symbol: BDKRB2
- Official Name: bradykinin receptor B2
- Aliases and Previous Symbols: N/A
- Entrez ID: 624
- UniProt: P30411
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator |
| regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator |
| bradykinin receptor activity |
| negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| type 1 angiotensin receptor binding |
| regulation of cellular response to osmotic stress |
| regulation of response to osmotic stress |
| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| response to salt stress |
| arachidonic acid secretion |
| arachidonate transport |
| negative regulation of peptidyl-serine phosphorylation |
| phosphatidylinositol phospholipase C activity |
| icosanoid secretion |
| regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| vasodilation |
| fatty acid derivative transport |
| vasoconstriction |
| icosanoid transport |
| negative regulation of signal transduction by p53 class mediator |
| regulation of vascular permeability |
| negative regulation of blood vessel diameter |
| smooth muscle contraction |
| regulation of vasoconstriction |
| positive regulation of blood vessel diameter |
| long-chain fatty acid transport |
| fatty acid transport |
| response to osmotic stress |
| acid secretion |
| negative regulation of intrinsic apoptotic signaling pathway |
| protease binding |
| monocarboxylic acid transport |
| regulation of peptidyl-serine phosphorylation |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| regulation of intrinsic apoptotic signaling pathway |
| vascular process in circulatory system |
| regulation of signal transduction by p53 class mediator |
| negative regulation of apoptotic signaling pathway |
| muscle contraction |
| endosome |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| organic acid transport |
| carboxylic acid transport |
| lipid transport |
| muscle system process |
| lipid localization |
| regulation of cytosolic calcium ion concentration |
| blood circulation |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| cellular calcium ion homeostasis |
| negative regulation of phosphorylation |
| calcium ion homeostasis |
| organic anion transport |
| cellular divalent inorganic cation homeostasis |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| inflammatory response |
| negative regulation of intracellular signal transduction |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| anion transport |
| regulation of system process |
| negative regulation of protein modification process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cation homeostasis |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| ion homeostasis |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| secretion |
| response to abiotic stimulus |
| negative regulation of signal transduction |
| G protein-coupled receptor signaling pathway |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| integral component of plasma membrane |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of cell death |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ZLN024 50μM R08 exp538 | 1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12342
- Expression level (log2 read counts): -0.58
Expression Distribution
BDKRB2 Expression in NALM6 Cells: -0.58
