BDNF
Gene Information
- Official Symbol: BDNF
- Official Name: brain derived neurotrophic factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 627
- UniProt: P23560
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| NGF |
GO Terms
| positive regulation of brain-derived neurotrophic factor receptor signaling pathway |
| regulation of brain-derived neurotrophic factor receptor signaling pathway |
| brain-derived neurotrophic factor receptor signaling pathway |
| positive regulation of non-membrane spanning protein tyrosine kinase activity |
| regulation of non-membrane spanning protein tyrosine kinase activity |
| collateral sprouting |
| positive regulation of receptor binding |
| positive regulation of collateral sprouting |
| nerve growth factor signaling pathway |
| negative regulation of myotube differentiation |
| regulation of collateral sprouting |
| neurotrophin TRK receptor signaling pathway |
| regulation of receptor binding |
| neurotrophin signaling pathway |
| activation of phospholipase C activity |
| regulation of protein localization to cell surface |
| negative regulation of striated muscle cell differentiation |
| positive regulation of phospholipase C activity |
| regulation of phospholipase C activity |
| cellular response to nerve growth factor stimulus |
| response to nerve growth factor |
| negative regulation of muscle cell differentiation |
| positive regulation of protein tyrosine kinase activity |
| regulation of myotube differentiation |
| positive regulation of phospholipase activity |
| positive regulation of synapse assembly |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| peripheral nervous system development |
| nerve development |
| positive regulation of axonogenesis |
| developmental cell growth |
| regulation of protein tyrosine kinase activity |
| cell growth |
| positive regulation of protein binding |
| synapse assembly |
| regulation of lipase activity |
| regulation of striated muscle cell differentiation |
| regulation of synapse assembly |
| regulation of extent of cell growth |
| developmental growth involved in morphogenesis |
| memory |
| synaptic vesicle |
| negative regulation of neuron apoptotic process |
| regulation of muscle cell differentiation |
| positive regulation of cell morphogenesis involved in differentiation |
| positive regulation of cell growth |
| growth factor activity |
| positive regulation of developmental growth |
| positive regulation of binding |
| regulation of cell size |
| regulation of axonogenesis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| regulation of synapse organization |
| regulation of protein binding |
| negative regulation of apoptotic signaling pathway |
| regulation of synapse structure or activity |
| regulation of peptidyl-tyrosine phosphorylation |
| cytoplasmic vesicle |
| learning or memory |
| positive regulation of growth |
| axon guidance |
| neuron projection guidance |
| synapse organization |
| positive regulation of neuron projection development |
| axon |
| cognition |
| regulation of cell morphogenesis involved in differentiation |
| regulation of neuron death |
| regulation of developmental growth |
| positive regulation of neuron differentiation |
| axonogenesis |
| regulation of cellular component size |
| regulation of binding |
| positive regulation of cell projection organization |
| developmental growth |
| growth |
| regulation of apoptotic signaling pathway |
| nuclear speck |
| axon development |
| regulation of cell growth |
| dendrite |
| cell morphogenesis involved in neuron differentiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| regulation of cellular protein localization |
| positive regulation of cell development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| behavior |
| positive regulation of kinase activity |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| neuron projection development |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| positive regulation of hydrolase activity |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| negative regulation of cell death |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Erlotinib 10μM R05 exp216 | -1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15331
- Expression level (log2 read counts): -1.39
Expression Distribution
BDNF Expression in NALM6 Cells: -1.39
