BDP1

Official Symbol: BDP1
Official Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Aliases and Previous Symbols: N/A
Entrez ID: 55814
UniProt: A6H8Y1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.002μM R01 exp60	1.73
MLN-4924 0.2μM R00 exp21	1.94
GSK626616 14μM R08 exp485	1.96
AICAR 240μM R03 exp116	2.03
AICAR 240μM R05 exp211	2.06
Atovaquone 15μM R08 exp451	2.19
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	2.29
Diepoxybutane 3μM R07 exp354	2.34
Etoposide 0.3μM R05 exp199	2.37

Global Fraction of Cell Lines Where Essential: 106/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	4/28
blood	3/28
bone	3/25
breast	6/33
central nervous system	7/56
cervix	0/4
colorectal	2/17
esophagus	2/13
fibroblast	0/1
gastric	3/15
kidney	2/21
liver	6/20
lung	10/75
lymphocyte	2/14
ovary	4/26
pancreas	3/24
peripheral nervous system	0/16
plasma cell	3/15
prostate	0/1
skin	2/24
soft tissue	1/7
thyroid	1/2
upper aerodigestive	5/22
urinary tract	3/29
uterus	2/5

Expression Distribution

TFIIIC-class transcription factor complex binding
transcription factor TFIIIB complex
RNA polymerase III preinitiation complex assembly
transcription initiation from RNA polymerase III promoter
transcription preinitiation complex assembly
transcription by RNA polymerase III
protein-DNA complex assembly
DNA-templated transcription, initiation
protein-DNA complex subunit organization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
cellular protein-containing complex assembly
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression