BFAR

Gene Information

Official Symbol: BFAR
Official Name: bifunctional apoptosis regulator
Aliases and Previous Symbols: N/A
Entrez ID: 51283
UniProt: Q9NZS9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. {ECO:0000269|PubMed:14502241}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15057
Expression level (log2 read counts): 6.04

Expression Distribution

SAM 1
zf-C3HC4

negative regulation of IRE1-mediated unfolded protein response
caspase binding
negative regulation of endoplasmic reticulum unfolded protein response
regulation of IRE1-mediated unfolded protein response
regulation of endoplasmic reticulum unfolded protein response
protein K63-linked ubiquitination
negative regulation of response to endoplasmic reticulum stress
protein K48-linked ubiquitination
protein autoubiquitination
protein binding, bridging
regulation of response to endoplasmic reticulum stress
integral component of endoplasmic reticulum membrane
ubiquitin protein ligase activity
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of cellular response to stress
protein modification by small protein conjugation
negative regulation of apoptotic process
cellular macromolecule catabolic process
negative regulation of programmed cell death
apoptotic process
protein modification by small protein conjugation or removal
negative regulation of cell death
endoplasmic reticulum
macromolecule catabolic process
programmed cell death
organonitrogen compound catabolic process
cell death
negative regulation of signal transduction
proteolysis
negative regulation of cell communication
negative regulation of signaling