BHMT2

Entrez Summary: Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
UniProt Summary: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. {ECO:0000269|PubMed:18230605}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

S-methylmethionine metabolic process
S-methylmethionine-homocysteine S-methyltransferase activity
betaine-homocysteine S-methyltransferase activity
amino acid salvage
L-methionine salvage
L-methionine biosynthetic process
methionine biosynthetic process
methionine metabolic process
sulfur amino acid biosynthetic process
S-adenosylmethionine metabolic process
amino-acid betaine metabolic process
aspartate family amino acid biosynthetic process
cellular metabolic compound salvage
sulfur amino acid metabolic process
aspartate family amino acid metabolic process
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
coenzyme metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
methylation
sulfur compound metabolic process
cofactor metabolic process
drug metabolic process
small molecule biosynthetic process
zinc ion binding
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
small molecule metabolic process