BICD1 [The Human Chemical-Genetic Interaction Map Project]

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======= BICD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BICD1
  * **<color #00a2e8>Official Name</color>**: BICD cargo adaptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=636|636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96G01|Q96G01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BICD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BICD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602204|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BicD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of proteinase activated receptor activity|
|host cell viral assembly compartment|
|tubulin complex|
|negative regulation of phospholipase C activity|
|proteinase activated receptor binding|
|regulation of phospholipase C-activating G protein-coupled receptor signaling pathway|
|minus-end-directed organelle transport along microtubule|
|positive regulation of protein localization to centrosome|
|negative regulation of phospholipase activity|
|regulation of protein localization to centrosome|
|intracellular mRNA localization|
|microtubule anchoring at microtubule organizing center|
|dynactin binding|
|cytoskeletal adaptor activity|
|stress granule assembly|
|negative regulation of lipase activity|
|dynein complex binding|
|microtubule anchoring|
|dynein intermediate chain binding|
|regulation of phospholipase C activity|
|negative regulation of G protein-coupled receptor signaling pathway|
|positive regulation of receptor-mediated endocytosis|
|cytoplasmic microtubule|
|regulation of phospholipase activity|
|organelle transport along microtubule|
|regulation of lipase activity|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|structural constituent of cytoskeleton|
|regulation of G protein-coupled receptor signaling pathway|
|Rab GTPase binding|
|transport along microtubule|
|trans-Golgi network|
|regulation of signaling receptor activity|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|regulation of microtubule cytoskeleton organization|
|regulation of endocytosis|
|RNA localization|
|regulation of microtubule-based process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|cytoplasmic vesicle|
|microtubule-based movement|
|positive regulation of cellular protein localization|
|establishment of organelle localization|
|cytoskeleton|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|microtubule cytoskeleton organization|
|centrosome|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|organelle localization|
|microtubule-based process|
|perinuclear region of cytoplasm|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|RNA processing|
|regulation of cellular localization|
|Golgi apparatus|
|positive regulation of transport|
|regulation of protein localization|
|cytoskeleton organization|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|intracellular transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|RNA metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.12|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.91|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12167
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BICD1 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>