BICD1
Gene Information
- Official Symbol: BICD1
- Official Name: BICD cargo adaptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 636
- UniProt: Q96G01
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
Pfam Domains GO Terms
Pfam Domains
| BicD |
GO Terms
| negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of proteinase activated receptor activity |
| host cell viral assembly compartment |
| tubulin complex |
| negative regulation of phospholipase C activity |
| proteinase activated receptor binding |
| regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| minus-end-directed organelle transport along microtubule |
| positive regulation of protein localization to centrosome |
| negative regulation of phospholipase activity |
| regulation of protein localization to centrosome |
| intracellular mRNA localization |
| microtubule anchoring at microtubule organizing center |
| dynactin binding |
| cytoskeletal adaptor activity |
| stress granule assembly |
| negative regulation of lipase activity |
| dynein complex binding |
| microtubule anchoring |
| dynein intermediate chain binding |
| regulation of phospholipase C activity |
| negative regulation of G protein-coupled receptor signaling pathway |
| positive regulation of receptor-mediated endocytosis |
| cytoplasmic microtubule |
| regulation of phospholipase activity |
| organelle transport along microtubule |
| regulation of lipase activity |
| regulation of receptor-mediated endocytosis |
| positive regulation of endocytosis |
| structural constituent of cytoskeleton |
| regulation of G protein-coupled receptor signaling pathway |
| Rab GTPase binding |
| transport along microtubule |
| trans-Golgi network |
| regulation of signaling receptor activity |
| cytoskeleton-dependent intracellular transport |
| microtubule-based transport |
| regulation of microtubule cytoskeleton organization |
| regulation of endocytosis |
| RNA localization |
| regulation of microtubule-based process |
| ribonucleoprotein complex assembly |
| ribonucleoprotein complex subunit organization |
| cytoplasmic vesicle |
| microtubule-based movement |
| positive regulation of cellular protein localization |
| establishment of organelle localization |
| cytoskeleton |
| negative regulation of hydrolase activity |
| ribonucleoprotein complex biogenesis |
| protein kinase binding |
| microtubule cytoskeleton organization |
| centrosome |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| organelle localization |
| microtubule-based process |
| perinuclear region of cytoplasm |
| viral process |
| protein localization to organelle |
| organelle assembly |
| symbiotic process |
| negative regulation of catalytic activity |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| RNA processing |
| regulation of cellular localization |
| Golgi apparatus |
| positive regulation of transport |
| regulation of protein localization |
| cytoskeleton organization |
| negative regulation of molecular function |
| positive regulation of cellular component organization |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| intracellular transport |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| cellular protein localization |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
| RNA metabolic process |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| regulation of transport |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R03 exp116 | -2.12 |
| NMS-873 0.07μM R07 exp380 | -1.91 |
| Amiloride 100μM R08 exp447 | -1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12167
- Expression level (log2 read counts): 4.81
Expression Distribution
BICD1 Expression in NALM6 Cells: 4.81
