BIN2 [The Human Chemical-Genetic Interaction Map Project]

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======= BIN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BIN2
  * **<color #00a2e8>Official Name</color>**: bridging integrator 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51411|51411]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBW5|Q9UBW5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BIN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BIN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605936|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BAR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|podosome assembly|
|plasma membrane tubulation|
|phagocytic cup|
|podosome|
|plasma membrane organization|
|cell projection|
|phospholipid binding|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|phagocytosis, engulfment|
|cell cortex|
|plasma membrane invagination|
|membrane invagination|
|cell chemotaxis|
|phagocytosis|
|endomembrane system organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|cell junction|
|chemotaxis|
|taxis|
|endocytosis|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|import into cell|
|regulated exocytosis|
|organelle assembly|
|leukocyte mediated immunity|
|exocytosis|
|membrane organization|
|leukocyte activation|
|cell migration|
|secretion by cell|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|secretion|
|locomotion|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.75|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.75|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9268
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BIN2 Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>