BIN2

Entrez Summary: N/A
UniProt Summary: Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. {ECO:0000269|PubMed:23285027}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

podosome assembly
plasma membrane tubulation
phagocytic cup
podosome
plasma membrane organization
cell projection
phospholipid binding
secretory granule lumen
ficolin-1-rich granule lumen
phagocytosis, engulfment
cell cortex
plasma membrane invagination
membrane invagination
cell chemotaxis
phagocytosis
endomembrane system organization
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
cell junction
chemotaxis
taxis
endocytosis
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
import into cell
regulated exocytosis
organelle assembly
leukocyte mediated immunity
exocytosis
membrane organization
leukocyte activation
cell migration
secretion by cell