BIN3 [The Human Chemical-Genetic Interaction Map Project]

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======= BIN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BIN3
  * **<color #00a2e8>Official Name</color>**: bridging integrator 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55909|55909]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQY0|Q9NQY0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BIN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BIN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606396|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in cytokinesis and septation where it has a role in the localization of F-actin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps5|
|BAR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell septum assembly|
|division septum assembly|
|unidimensional cell growth|
|myoblast migration involved in skeletal muscle regeneration|
|actin cortical patch localization|
|myoblast migration|
|cytoskeletal adaptor activity|
|actin cortical patch|
|plasma membrane tubulation|
|muscle cell migration|
|skeletal muscle fiber development|
|myotube cell development|
|regulation of lamellipodium assembly|
|skeletal muscle tissue regeneration|
|cytokinetic process|
|regulation of lamellipodium organization|
|myotube differentiation|
|muscle fiber development|
|tissue regeneration|
|cytoskeletal protein binding|
|actin filament|
|cell growth|
|plasma membrane organization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|developmental growth involved in morphogenesis|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|muscle cell development|
|lipid binding|
|regeneration|
|regulation of plasma membrane bounded cell projection assembly|
|striated muscle cell differentiation|
|regulation of cell projection assembly|
|actin filament organization|
|muscle cell differentiation|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|developmental growth|
|growth|
|endomembrane system organization|
|supramolecular fiber organization|
|muscle structure development|
|wound healing|
|cell division|
|actin cytoskeleton organization|
|endocytosis|
|actin filament-based process|
|response to wounding|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|cellular component morphogenesis|
|membrane organization|
|regulation of cellular component biogenesis|
|cell migration|
|cell cycle process|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|locomotion|
|cell cycle|
|movement of cell or subcellular component|
|cell development|
|tissue development|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18794
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BIN3 Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>