BIN3

Entrez Summary: N/A
UniProt Summary: Involved in cytokinesis and septation where it has a role in the localization of F-actin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Vps5
BAR

cell septum assembly
division septum assembly
unidimensional cell growth
myoblast migration involved in skeletal muscle regeneration
actin cortical patch localization
myoblast migration
cytoskeletal adaptor activity
actin cortical patch
plasma membrane tubulation
muscle cell migration
skeletal muscle fiber development
myotube cell development
regulation of lamellipodium assembly
skeletal muscle tissue regeneration
cytokinetic process
regulation of lamellipodium organization
myotube differentiation
muscle fiber development
tissue regeneration
cytoskeletal protein binding
actin filament
cell growth
plasma membrane organization
cytoskeleton-dependent cytokinesis
cytokinesis
developmental growth involved in morphogenesis
skeletal muscle tissue development
skeletal muscle organ development
striated muscle cell development
muscle cell development
lipid binding
regeneration
regulation of plasma membrane bounded cell projection assembly
striated muscle cell differentiation
regulation of cell projection assembly
actin filament organization
muscle cell differentiation
striated muscle tissue development
muscle organ development
muscle tissue development