BLOC1S1

Entrez Summary: N/A
UniProt Summary: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:25898167}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

platelet dense granule organization
BORC complex
synaptic vesicle transport along microtubule
anterograde synaptic vesicle transport
synaptic vesicle cytoskeletal transport
BLOC-1 complex
melanosome organization
pigment granule organization
secretory granule organization
synaptic vesicle transport
synaptic vesicle localization
vesicle transport along microtubule
lysosome localization
anterograde axonal transport
cellular pigmentation
vesicle cytoskeletal trafficking
axonal transport
axon cytoplasm
axo-dendritic transport
mitochondrial intermembrane space
organelle transport along microtubule
aerobic respiration
pigmentation
peptidyl-lysine acetylation
protein acetylation
transport along microtubule
cellular respiration
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
microtubule-based transport
vesicle localization
protein acylation
endosomal transport
energy derivation by oxidation of organic compounds
microtubule-based movement
vesicle organization
lysosomal membrane
peptidyl-lysine modification
establishment of organelle localization
mitochondrial matrix