BLOC1S4

• Official Symbol: BLOC1S4
• Official Name: biogenesis of lysosomal organelles complex 1 subunit 4
• Aliases and Previous Symbols: N/A
• Entrez ID: 55330
• UniProt: Q9NUP1
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: N/A
• UniProt Summary: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:17182842}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 17386
• Expression level (log2 read counts): 3.49

Expression Distribution

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BLOC1S4 Expression in NALM6 Cells: 3.49