BLVRB

Entrez Summary: N/A
UniProt Summary: Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. {ECO:0000269|PubMed:10620517}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Epimerase
NmrA

riboflavin reductase (NADPH) activity
biliverdin reductase activity
heme catabolic process
tetrapyrrole catabolic process
pigment catabolic process
porphyrin-containing compound catabolic process
heme metabolic process
porphyrin-containing compound metabolic process
terminal bouton
tetrapyrrole metabolic process
cofactor catabolic process
pigment metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
cofactor metabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
oxidation-reduction process
organonitrogen compound catabolic process
organic substance catabolic process
cellular catabolic process