BMP10

Gene Information

Official Symbol: BMP10
Official Name: bone morphogenetic protein 10
Aliases and Previous Symbols: N/A
Entrez ID: 27302
UniProt: O95393
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016].
UniProt Summary: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. {ECO:0000269|PubMed:16049014, ECO:0000269|PubMed:17068149, ECO:0000269|PubMed:20608934}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14089
Expression level (log2 read counts): -7.68

Expression Distribution

TGFb propeptide
TGF beta

positive regulation of sarcomere organization
atrial cardiac muscle tissue morphogenesis
receptor serine/threonine kinase binding
positive regulation of cell proliferation involved in heart morphogenesis
atrial cardiac muscle tissue development
regulation of sarcomere organization
telethonin binding
regulation of cardiac muscle adaptation
regulation of cardiac muscle hypertrophy in response to stress
ventricular cardiac muscle cell development
heart trabecula formation
pathway-restricted SMAD protein phosphorylation
cardiac muscle cell proliferation
adult heart development
striated muscle cell proliferation
ventricular cardiac muscle cell differentiation
regulation of cell proliferation involved in heart morphogenesis
muscle cell proliferation
trabecula formation
activin receptor signaling pathway
positive regulation of cardiac muscle cell proliferation
negative regulation of cardiac muscle hypertrophy
cardiac muscle tissue growth
heart growth
negative regulation of muscle hypertrophy
cardiac atrium morphogenesis
positive regulation of cardiac muscle hypertrophy
positive regulation of muscle hypertrophy
heart trabecula morphogenesis
positive regulation of cardiac muscle tissue growth
positive regulation of cartilage development
cardiac atrium development
positive regulation of heart growth
regulation of heart morphogenesis
regulation of cardiac muscle cell proliferation
transforming growth factor beta receptor binding
positive regulation of cardiac muscle tissue development
trabecula morphogenesis
sarcomere organization
positive regulation of organ growth