BMP5 [The Human Chemical-Genetic Interaction Map Project]

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======= BMP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMP5
  * **<color #00a2e8>Official Name</color>**: bone morphogenetic protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=653|653]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22003|P22003]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112265|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Induces cartilage and bone formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|allantois development|
|neural fold elevation formation|
|negative regulation of aldosterone metabolic process|
|negative regulation of cortisol biosynthetic process|
|negative regulation of aldosterone biosynthetic process|
|anterior head development|
|negative regulation of glucocorticoid biosynthetic process|
|negative regulation of glucocorticoid metabolic process|
|negative regulation of steroid hormone biosynthetic process|
|negative regulation of insulin-like growth factor receptor signaling pathway|
|regulation of cortisol biosynthetic process|
|chorio-allantoic fusion|
|regulation of aldosterone metabolic process|
|regulation of aldosterone biosynthetic process|
|neural fold formation|
|regulation of glucocorticoid biosynthetic process|
|negative regulation of mononuclear cell migration|
|pericardium morphogenesis|
|extraembryonic membrane development|
|regulation of glucocorticoid metabolic process|
|negative regulation of hormone biosynthetic process|
|regulation of steroid hormone biosynthetic process|
|BMP receptor binding|
|negative regulation of hormone metabolic process|
|negative regulation of alcohol biosynthetic process|
|type B pancreatic cell development|
|regulation of ketone biosynthetic process|
|morphogenesis of an epithelial fold|
|glandular epithelial cell development|
|type B pancreatic cell differentiation|
|endocardial cushion formation|
|enteroendocrine cell differentiation|
|pericardium development|
|labyrinthine layer morphogenesis|
|regulation of insulin-like growth factor receptor signaling pathway|
|male genitalia development|
|negative regulation of steroid biosynthetic process|
|negative regulation of steroid metabolic process|
|pharyngeal system development|
|embryonic placenta morphogenesis|
|negative regulation of epithelial to mesenchymal transition|
|regulation of hormone biosynthetic process|
|heart trabecula morphogenesis|
|endocardial cushion morphogenesis|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|endocrine pancreas development|
|regulation of hormone metabolic process|
|glandular epithelial cell differentiation|
|transforming growth factor beta receptor binding|
|endocardial cushion development|
|trabecula morphogenesis|
|negative regulation of leukocyte migration|
|regulation of mononuclear cell migration|
|labyrinthine layer development|
|genitalia development|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of lipid biosynthetic process|
|morphogenesis of an epithelial sheet|
|columnar/cuboidal epithelial cell development|
|mesenchyme morphogenesis|
|SMAD protein signal transduction|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of pathway-restricted SMAD protein phosphorylation|
|pancreas development|
|positive regulation of dendrite development|
|cardiac septum morphogenesis|
|regulation of alcohol biosynthetic process|
|negative regulation of lipid metabolic process|
|regulation of epithelial to mesenchymal transition|
|embryonic placenta development|
|regulation of steroid biosynthetic process|
|BMP signaling pathway|
|negative regulation of small molecule metabolic process|
|columnar/cuboidal epithelial cell differentiation|
|primary neural tube formation|
|negative regulation of extrinsic apoptotic signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|neural tube formation|
|cardiac septum development|
|regulation of steroid metabolic process|
|endocrine system development|
|embryonic epithelial tube formation|
|cardiac chamber morphogenesis|
|epithelial tube formation|
|vesicle|
|morphogenesis of embryonic epithelium|
|tube formation|
|regulation of dendrite development|
|hindbrain development|
|placenta development|
|regulation of extrinsic apoptotic signaling pathway|
|male sex differentiation|
|neural tube development|
|cardiac muscle tissue development|
|growth factor activity|
|cardiac chamber development|
|cartilage development|
|regulation of cellular ketone metabolic process|
|cytokine activity|
|regulation of lipid biosynthetic process|
|positive regulation of epithelial cell proliferation|
|epithelial cell development|
|regulation of leukocyte migration|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|ear development|
|mesenchyme development|
|connective tissue development|
|negative regulation of apoptotic signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|heart morphogenesis|
|negative regulation of cell migration|
|ossification|
|sex differentiation|
|negative regulation of cell motility|
|positive regulation of neuron projection development|
|striated muscle tissue development|
|muscle tissue development|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of epithelial cell proliferation|
|positive regulation of neuron differentiation|
|in utero embryonic development|
|positive regulation of cell projection organization|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|cellular component|
|positive regulation of neurogenesis|
|skeletal system development|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|heart development|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.12|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.03|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.92|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.82|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.82|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.72|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.71|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17299
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMP5 Expression in NALM6 Cells: -0.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>