BMP5
Gene Information
- Official Symbol: BMP5
- Official Name: bone morphogenetic protein 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 653
- UniProt: P22003
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Induces cartilage and bone formation.
Pfam Domains GO Terms
Pfam Domains
| TGFb propeptide |
| TGF beta |
GO Terms
| allantois development |
| neural fold elevation formation |
| negative regulation of aldosterone metabolic process |
| negative regulation of cortisol biosynthetic process |
| negative regulation of aldosterone biosynthetic process |
| anterior head development |
| negative regulation of glucocorticoid biosynthetic process |
| negative regulation of glucocorticoid metabolic process |
| negative regulation of steroid hormone biosynthetic process |
| negative regulation of insulin-like growth factor receptor signaling pathway |
| regulation of cortisol biosynthetic process |
| chorio-allantoic fusion |
| regulation of aldosterone metabolic process |
| regulation of aldosterone biosynthetic process |
| neural fold formation |
| regulation of glucocorticoid biosynthetic process |
| negative regulation of mononuclear cell migration |
| pericardium morphogenesis |
| extraembryonic membrane development |
| regulation of glucocorticoid metabolic process |
| negative regulation of hormone biosynthetic process |
| regulation of steroid hormone biosynthetic process |
| BMP receptor binding |
| negative regulation of hormone metabolic process |
| negative regulation of alcohol biosynthetic process |
| type B pancreatic cell development |
| regulation of ketone biosynthetic process |
| morphogenesis of an epithelial fold |
| glandular epithelial cell development |
| type B pancreatic cell differentiation |
| endocardial cushion formation |
| enteroendocrine cell differentiation |
| pericardium development |
| labyrinthine layer morphogenesis |
| regulation of insulin-like growth factor receptor signaling pathway |
| male genitalia development |
| negative regulation of steroid biosynthetic process |
| negative regulation of steroid metabolic process |
| pharyngeal system development |
| embryonic placenta morphogenesis |
| negative regulation of epithelial to mesenchymal transition |
| regulation of hormone biosynthetic process |
| heart trabecula morphogenesis |
| endocardial cushion morphogenesis |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| endocrine pancreas development |
| regulation of hormone metabolic process |
| glandular epithelial cell differentiation |
| transforming growth factor beta receptor binding |
| endocardial cushion development |
| trabecula morphogenesis |
| negative regulation of leukocyte migration |
| regulation of mononuclear cell migration |
| labyrinthine layer development |
| genitalia development |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of lipid biosynthetic process |
| morphogenesis of an epithelial sheet |
| columnar/cuboidal epithelial cell development |
| mesenchyme morphogenesis |
| SMAD protein signal transduction |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| regulation of pathway-restricted SMAD protein phosphorylation |
| pancreas development |
| positive regulation of dendrite development |
| cardiac septum morphogenesis |
| regulation of alcohol biosynthetic process |
| negative regulation of lipid metabolic process |
| regulation of epithelial to mesenchymal transition |
| embryonic placenta development |
| regulation of steroid biosynthetic process |
| BMP signaling pathway |
| negative regulation of small molecule metabolic process |
| columnar/cuboidal epithelial cell differentiation |
| primary neural tube formation |
| negative regulation of extrinsic apoptotic signaling pathway |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| response to BMP |
| cellular response to BMP stimulus |
| neural tube formation |
| cardiac septum development |
| regulation of steroid metabolic process |
| endocrine system development |
| embryonic epithelial tube formation |
| cardiac chamber morphogenesis |
| epithelial tube formation |
| vesicle |
| morphogenesis of embryonic epithelium |
| tube formation |
| regulation of dendrite development |
| hindbrain development |
| placenta development |
| regulation of extrinsic apoptotic signaling pathway |
| male sex differentiation |
| neural tube development |
| cardiac muscle tissue development |
| growth factor activity |
| cardiac chamber development |
| cartilage development |
| regulation of cellular ketone metabolic process |
| cytokine activity |
| regulation of lipid biosynthetic process |
| positive regulation of epithelial cell proliferation |
| epithelial cell development |
| regulation of leukocyte migration |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| ear development |
| mesenchyme development |
| connective tissue development |
| negative regulation of apoptotic signaling pathway |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| heart morphogenesis |
| negative regulation of cell migration |
| ossification |
| sex differentiation |
| negative regulation of cell motility |
| positive regulation of neuron projection development |
| striated muscle tissue development |
| muscle tissue development |
| epithelial tube morphogenesis |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| regulation of epithelial cell proliferation |
| positive regulation of neuron differentiation |
| in utero embryonic development |
| positive regulation of cell projection organization |
| regulation of lipid metabolic process |
| regulation of apoptotic signaling pathway |
| reproductive structure development |
| regulation of small molecule metabolic process |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| negative regulation of immune system process |
| cellular component |
| positive regulation of neurogenesis |
| skeletal system development |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| cell-cell adhesion |
| heart development |
| response to growth factor |
| regulation of hormone levels |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| brain development |
| regulation of MAPK cascade |
| head development |
| regulation of neurogenesis |
| tube development |
| regulation of cell migration |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| KU-0063794 3.8μM R02 exp71 | -2.12 |
| Talazoparib 0.006μM R06 exp299 | -2.03 |
| Amiloride 100μM R08 exp447 | -1.92 |
| MLN-4924 2μM R00 exp22 | -1.82 |
| PU-H71 1μM R08 exp515 | -1.82 |
| S-trityl-L-cysteine 0.5μM R05 exp243 | -1.72 |
| CI-1040 9.5μM R08 exp472 | 1.71 |
| 4-Nitroquinoline-1-oxide 0.5μM R08 exp446 | 2.32 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17299
- Expression level (log2 read counts): -0.84
Expression Distribution
BMP5 Expression in NALM6 Cells: -0.84
