BMP6 [The Human Chemical-Genetic Interaction Map Project]

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======= BMP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMP6
  * **<color #00a2e8>Official Name</color>**: bone morphogenetic protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=654|654]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22004|P22004]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112266|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Induces cartilage and bone formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGFb propeptide|
|TGF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of aldosterone secretion|
|positive regulation of mineralocorticoid secretion|
|positive regulation of aldosterone metabolic process|
|positive regulation of aldosterone biosynthetic process|
|positive regulation of steroid hormone biosynthetic process|
|regulation of mineralocorticoid secretion|
|regulation of aldosterone secretion|
|regulation of aldosterone metabolic process|
|regulation of aldosterone biosynthetic process|
|negative regulation of cell-cell adhesion mediated by cadherin|
|positive regulation of corticosteroid hormone secretion|
|positive regulation of lipopolysaccharide-mediated signaling pathway|
|multicellular organismal iron ion homeostasis|
|positive regulation of steroid hormone secretion|
|regulation of steroid hormone biosynthetic process|
|cellular response to iron ion|
|BMP receptor binding|
|positive regulation of hormone biosynthetic process|
|positive regulation of vascular permeability|
|positive regulation of SMAD protein signal transduction|
|type B pancreatic cell development|
|positive regulation of hormone metabolic process|
|regulation of ketone biosynthetic process|
|positive regulation of endothelial cell differentiation|
|regulation of corticosteroid hormone secretion|
|regulation of cell-cell adhesion mediated by cadherin|
|positive regulation of steroid biosynthetic process|
|regulation of steroid hormone secretion|
|glandular epithelial cell development|
|type B pancreatic cell differentiation|
|response to magnesium ion|
|enteroendocrine cell differentiation|
|positive regulation of chondrocyte differentiation|
|negative regulation of adherens junction organization|
|regulation of SMAD protein signal transduction|
|male genitalia development|
|positive regulation of alcohol biosynthetic process|
|regulation of lipopolysaccharide-mediated signaling pathway|
|positive regulation of steroid metabolic process|
|regulation of hormone biosynthetic process|
|endochondral ossification|
|replacement ossification|
|positive regulation of cartilage development|
|response to iron ion|
|regulation of endothelial cell differentiation|
|regulation of vascular permeability|
|regulation of hormone metabolic process|
|glandular epithelial cell differentiation|
|endocrine pancreas development|
|positive regulation of bone mineralization|
|transforming growth factor beta receptor binding|
|regulation of endocrine process|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|genitalia development|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|columnar/cuboidal epithelial cell development|
|regulation of chondrocyte differentiation|
|SMAD protein signal transduction|
|positive regulation of osteoblast differentiation|
|positive regulation of epithelial cell differentiation|
|regulation of pathway-restricted SMAD protein phosphorylation|
|positive regulation of lipid transport|
|cellular iron ion homeostasis|
|response to activity|
|regulation of adherens junction organization|
|regulation of cartilage development|
|endochondral bone morphogenesis|
|pancreas development|
|regulation of alcohol biosynthetic process|
|regulation of bone mineralization|
|positive regulation of lipid biosynthetic process|
|cellular response to mechanical stimulus|
|iron ion homeostasis|
|positive regulation of lipid localization|
|positive regulation of ossification|
|regulation of steroid biosynthetic process|
|BMP signaling pathway|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|positive regulation of endothelial cell proliferation|
|columnar/cuboidal epithelial cell differentiation|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|cellular transition metal ion homeostasis|
|regulation of lipid transport|
|response to retinoic acid|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|regulation of steroid metabolic process|
|endocrine system development|
|osteoblast differentiation|
|positive regulation of hormone secretion|
|regulation of endothelial cell proliferation|
|transition metal ion homeostasis|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|regulation of epithelial cell differentiation|
|positive regulation of lipid metabolic process|
|vesicle|
|response to glucocorticoid|
|male sex differentiation|
|response to corticosteroid|
|growth factor activity|
|vascular process in circulatory system|
|regulation of cellular ketone metabolic process|
|cartilage development|
|cytokine activity|
|negative regulation of cell-cell adhesion|
|regulation of lipid biosynthetic process|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to metal ion|
|epithelial cell development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|response to mechanical stimulus|
|cellular response to inorganic substance|
|connective tissue development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|ossification|
|sex differentiation|
|kidney development|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|renal system development|
|positive regulation of peptide secretion|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|urogenital system development|
|multicellular organismal homeostasis|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|response to acid chemical|
|eye development|
|visual system development|
|positive regulation of response to biotic stimulus|
|positive regulation of neuron differentiation|
|sensory system development|
|response to metal ion|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|reproductive structure development|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|reproductive system development|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|protein heterodimerization activity|
|skeletal system development|
|regulation of peptide secretion|
|inflammatory response|
|cellular response to growth factor stimulus|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|response to growth factor|
|regulation of hormone levels|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|cellular metal ion homeostasis|
|regulation of system process|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|regulation of cell adhesion|
|epithelial cell differentiation|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of secretion|
|regulation of neurogenesis|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|chemical homeostasis|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.95|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10454
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMP6 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>