BMP6
Gene Information
- Official Symbol: BMP6
- Official Name: bone morphogenetic protein 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 654
- UniProt: P22004
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Induces cartilage and bone formation.
Pfam Domains GO Terms
Pfam Domains
| TGFb propeptide |
| TGF beta |
GO Terms
| positive regulation of aldosterone secretion |
| positive regulation of mineralocorticoid secretion |
| positive regulation of aldosterone metabolic process |
| positive regulation of aldosterone biosynthetic process |
| positive regulation of steroid hormone biosynthetic process |
| regulation of mineralocorticoid secretion |
| regulation of aldosterone secretion |
| regulation of aldosterone metabolic process |
| regulation of aldosterone biosynthetic process |
| negative regulation of cell-cell adhesion mediated by cadherin |
| positive regulation of corticosteroid hormone secretion |
| positive regulation of lipopolysaccharide-mediated signaling pathway |
| multicellular organismal iron ion homeostasis |
| positive regulation of steroid hormone secretion |
| regulation of steroid hormone biosynthetic process |
| cellular response to iron ion |
| BMP receptor binding |
| positive regulation of hormone biosynthetic process |
| positive regulation of vascular permeability |
| positive regulation of SMAD protein signal transduction |
| type B pancreatic cell development |
| positive regulation of hormone metabolic process |
| regulation of ketone biosynthetic process |
| positive regulation of endothelial cell differentiation |
| regulation of corticosteroid hormone secretion |
| regulation of cell-cell adhesion mediated by cadherin |
| positive regulation of steroid biosynthetic process |
| regulation of steroid hormone secretion |
| glandular epithelial cell development |
| type B pancreatic cell differentiation |
| response to magnesium ion |
| enteroendocrine cell differentiation |
| positive regulation of chondrocyte differentiation |
| negative regulation of adherens junction organization |
| regulation of SMAD protein signal transduction |
| male genitalia development |
| positive regulation of alcohol biosynthetic process |
| regulation of lipopolysaccharide-mediated signaling pathway |
| positive regulation of steroid metabolic process |
| regulation of hormone biosynthetic process |
| endochondral ossification |
| replacement ossification |
| positive regulation of cartilage development |
| response to iron ion |
| regulation of endothelial cell differentiation |
| regulation of vascular permeability |
| regulation of hormone metabolic process |
| glandular epithelial cell differentiation |
| endocrine pancreas development |
| positive regulation of bone mineralization |
| transforming growth factor beta receptor binding |
| regulation of endocrine process |
| positive regulation of biomineralization |
| positive regulation of biomineral tissue development |
| genitalia development |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| columnar/cuboidal epithelial cell development |
| regulation of chondrocyte differentiation |
| SMAD protein signal transduction |
| positive regulation of osteoblast differentiation |
| positive regulation of epithelial cell differentiation |
| regulation of pathway-restricted SMAD protein phosphorylation |
| positive regulation of lipid transport |
| cellular iron ion homeostasis |
| response to activity |
| regulation of adherens junction organization |
| regulation of cartilage development |
| endochondral bone morphogenesis |
| pancreas development |
| regulation of alcohol biosynthetic process |
| regulation of bone mineralization |
| positive regulation of lipid biosynthetic process |
| cellular response to mechanical stimulus |
| iron ion homeostasis |
| positive regulation of lipid localization |
| positive regulation of ossification |
| regulation of steroid biosynthetic process |
| BMP signaling pathway |
| regulation of biomineralization |
| regulation of biomineral tissue development |
| positive regulation of endothelial cell proliferation |
| columnar/cuboidal epithelial cell differentiation |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| response to BMP |
| cellular response to BMP stimulus |
| cellular transition metal ion homeostasis |
| regulation of lipid transport |
| response to retinoic acid |
| regulation of osteoblast differentiation |
| bone morphogenesis |
| regulation of steroid metabolic process |
| endocrine system development |
| osteoblast differentiation |
| positive regulation of hormone secretion |
| regulation of endothelial cell proliferation |
| transition metal ion homeostasis |
| regulation of lipid localization |
| positive regulation of small molecule metabolic process |
| regulation of epithelial cell differentiation |
| positive regulation of lipid metabolic process |
| vesicle |
| response to glucocorticoid |
| male sex differentiation |
| response to corticosteroid |
| growth factor activity |
| vascular process in circulatory system |
| regulation of cellular ketone metabolic process |
| cartilage development |
| cytokine activity |
| negative regulation of cell-cell adhesion |
| regulation of lipid biosynthetic process |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cellular response to metal ion |
| epithelial cell development |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| bone development |
| response to mechanical stimulus |
| cellular response to inorganic substance |
| connective tissue development |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| regulation of peptidyl-tyrosine phosphorylation |
| ossification |
| sex differentiation |
| kidney development |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| negative regulation of cell adhesion |
| renal system development |
| positive regulation of peptide secretion |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| urogenital system development |
| multicellular organismal homeostasis |
| response to steroid hormone |
| regulation of epithelial cell proliferation |
| cellular response to external stimulus |
| response to acid chemical |
| eye development |
| visual system development |
| positive regulation of response to biotic stimulus |
| positive regulation of neuron differentiation |
| sensory system development |
| response to metal ion |
| blood circulation |
| regulation of lipid metabolic process |
| circulatory system process |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| reproductive structure development |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| reproductive system development |
| positive regulation of secretion |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of neurogenesis |
| protein heterodimerization activity |
| skeletal system development |
| regulation of peptide secretion |
| inflammatory response |
| cellular response to growth factor stimulus |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| response to growth factor |
| regulation of hormone levels |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| cellular metal ion homeostasis |
| regulation of system process |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| regulation of cell adhesion |
| epithelial cell differentiation |
| negative regulation of cellular component organization |
| cation homeostasis |
| regulation of protein transport |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of multi-organism process |
| ion homeostasis |
| regulation of secretion |
| regulation of neurogenesis |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| cellular homeostasis |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| positive regulation of transport |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| chemical homeostasis |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| defense response |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| LLY-283 2.6μM R06 exp290 | -1.95 |
| Arsenate 40μM R06 exp264 | -1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10454
- Expression level (log2 read counts): -4.6
Expression Distribution
BMP6 Expression in NALM6 Cells: -4.6
