BOD1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= BOD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BOD1
  * **<color #00a2e8>Official Name</color>**: biorientation of chromosomes in cell division 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91272|91272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96IK1|Q96IK1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BOD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BOD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. {ECO:0000269|PubMed:17938248}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COMPASS-Shg1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic sister chromatid biorientation|
|mitotic sister chromatid cohesion, centromeric|
|sister chromatid biorientation|
|centromeric sister chromatid cohesion|
|condensed chromosome outer kinetochore|
|attachment of mitotic spindle microtubules to kinetochore|
|mitotic sister chromatid cohesion|
|protein localization to chromosome, centromeric region|
|attachment of spindle microtubules to kinetochore|
|protein phosphatase 2A binding|
|protein phosphatase inhibitor activity|
|spindle microtubule|
|mitotic metaphase plate congression|
|sister chromatid cohesion|
|metaphase plate congression|
|negative regulation of phosphoprotein phosphatase activity|
|protein localization to chromosome|
|negative regulation of protein dephosphorylation|
|establishment of chromosome localization|
|chromosome localization|
|negative regulation of phosphatase activity|
|mitotic sister chromatid segregation|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|spindle pole|
|regulation of protein dephosphorylation|
|sister chromatid segregation|
|mitotic nuclear division|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|nuclear chromosome segregation|
|chromosome segregation|
|nuclear division|
|organelle fission|
|establishment of organelle localization|
|negative regulation of hydrolase activity|
|centrosome|
|cell division|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|mitotic cell cycle|
|protein localization to organelle|
|negative regulation of catalytic activity|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.12|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.99|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.89|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.87|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.85|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.81|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13705
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BOD1 Expression in NALM6 Cells: 4.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>