BPTF [The Human Chemical-Genetic Interaction Map Project]

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======= BPTF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BPTF
  * **<color #00a2e8>Official Name</color>**: bromodomain PHD finger transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2186|2186]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12830|Q12830]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BPTF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BPTF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601819|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|DDT|
|Bromodomain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NURF complex|
|DNA-dependent ATPase activity|
|endoderm development|
|embryonic placenta development|
|placenta development|
|chromatin remodeling|
|anterior/posterior pattern specification|
|nuclear chromatin|
|transcription factor binding|
|regionalization|
|in utero embryonic development|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|chromatin organization|
|brain development|
|head development|
|negative regulation of transcription by RNA polymerase II|
|embryo development|
|central nervous system development|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.71|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.71|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.71|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.73|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.73|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.73|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.73|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.76|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.78|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.83|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.87|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.94|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.97|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.01|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.11|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.14|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.2|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.26|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.27|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.28|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.31|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.37|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.38|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.38|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.46|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.47|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.65|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.71|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.82|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.96|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.08|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.34|
|[[:results:exp135|MS023 7μM R03 exp135]]|4.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:faf2|FAF2]]|0.5|
|[[:human genes:d:dohh|DOHH]]|0.49|
|[[:human genes:n:nsd1|NSD1]]|0.487|
|[[:human genes:v:vdac2|VDAC2]]|0.477|
|[[:human genes:r:romo1|ROMO1]]|0.455|
|[[:human genes:r:rptor|RPTOR]]|0.454|
|[[:human genes:m:mlst8|MLST8]]|0.452|
|[[:human genes:m:mtor|MTOR]]|0.449|
|[[:human genes:b:bak1|BAK1]]|0.438|
|[[:human genes:w:wdr24|WDR24]]|0.432|
|[[:human genes:i:impdh2|IMPDH2]]|0.427|
|[[:human genes:t:trim28|TRIM28]]|0.421|
|[[:human genes:i:id3|ID3]]|0.42|
|[[:human genes:p:plaa|PLAA]]|0.419|
|[[:human genes:b:bap1|BAP1]]|0.416|
|[[:human genes:a:asxl2|ASXL2]]|0.416|
|[[:human genes:b:brpf1|BRPF1]]|0.413|
|[[:human genes:k:kdsr|KDSR]]|0.413|
|[[:human genes:s:serf2|SERF2]]|0.412|
|[[:human genes:w:wdr59|WDR59]]|0.408|
|[[:human genes:u:ubqln1|UBQLN1]]|0.407|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.402|
|[[:human genes:m:meaf6|MEAF6]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 29/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|2/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1057
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BPTF Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>