BPTF

Gene Information

Official Symbol: BPTF
Official Name: bromodomain PHD finger transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 2186
UniProt: Q12830
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008].
UniProt Summary: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Centrinone 0.5μM R07 exp343	1.71
GSK-J4 1-1.25μM to day4 R07 exp363	1.71
Staurosporine 0.02μM R08 exp524	1.71
Mubritinib 0.2μM R02 exp65	1.73
QNZ 0.01μM R05 exp241	1.73
TRAIL 50ng/ml R00 exp36	1.73
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.73
NMS-873 0.07μM R07 exp380	1.76
Ethanol 0.01 R05 exp234	1.78
Mdivi-1 15μM R05 exp217	1.83
MS023 2μM R03 exp134	1.87
Deferoxamine 11μM R07 exp350	1.94
Quercetin 20μM R08 exp517	1.97
Nocodazole 0.2μM R02 exp64	2
MLN-4924 2μM R00 exp22	2.01
BI-D1870 3.15μM R02 exp66	2.11
LY2090314 0.003μM R08 exp500 no dilution day6	2.14
DABN racemic mixture R03 exp93	2.2
UMK57 1μM R01 exp59	2.26
Milciclib 2μM R08 exp502	2.27
LLY-283 2.6μM R06 exp290	2.28
Benzoate 20000μM R08 exp456	2.31
Fluvastatin 2.2μM R06 exp282	2.37
2-Deoxy-D-glucose 800μM R05 exp214	2.38
Amiloride 100μM R08 exp447	2.38
GSK626616 14μM R08 exp485	2.46
RO-3307 4.7μM R02 exp80	2.47
UM131593 0.2μM R03 exp106	2.65
Cerivastatin 0.15μM R05 exp226	2.71
LY2090314 0.003μM R08 exp499	2.82
Actinomycin-D 0.001μM R00 exp3	2.96
AICAR 240μM R05 exp211	3.08
AICAR 240μM R03 exp116	3.34
MS023 7μM R03 exp135	4.35

Gene	Correlation
FAF2	0.5
DOHH	0.49
NSD1	0.487
VDAC2	0.477
ROMO1	0.455
RPTOR	0.454
MLST8	0.452
MTOR	0.449
BAK1	0.438
WDR24	0.432
IMPDH2	0.427
TRIM28	0.421
ID3	0.42
PLAA	0.419
BAP1	0.416
ASXL2	0.416
BRPF1	0.413
KDSR	0.413
SERF2	0.412
WDR59	0.408
UBQLN1	0.407
MAPKAP1	0.402
MEAF6	0.401

Global Fraction of Cell Lines Where Essential: 29/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	2/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	3/75
lymphocyte	2/14
ovary	0/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	1/15
prostate	0/1
skin	5/24
soft tissue	0/7
thyroid	1/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1057
Expression level (log2 read counts): 8.23

Expression Distribution

PHD
DDT
Bromodomain

NURF complex
DNA-dependent ATPase activity
endoderm development
embryonic placenta development
placenta development
chromatin remodeling
anterior/posterior pattern specification
nuclear chromatin
transcription factor binding
regionalization
in utero embryonic development
sequence-specific DNA binding
reproductive structure development
reproductive system development
embryonic organ development
pattern specification process
chordate embryonic development
embryo development ending in birth or egg hatching
developmental process involved in reproduction
chromatin organization
brain development
head development
negative regulation of transcription by RNA polymerase II
embryo development
central nervous system development
chromosome organization
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
positive regulation of nucleic acid-templated transcription