BRAP [The Human Chemical-Genetic Interaction Map Project]

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======= BRAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRAP
  * **<color #00a2e8>Official Name</color>**: BRCA1 associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8315|8315]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z569|Q7Z569]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604986|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-UBP|
|BRAP2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear localization sequence binding|
|ubiquitin ligase complex|
|nucleic acid binding|
|ubiquitin protein ligase activity|
|nuclear membrane|
|ubiquitin-protein transferase activity|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|protein ubiquitination|
|protein modification by small protein conjugation|
|zinc ion binding|
|protein phosphorylation|
|protein modification by small protein conjugation or removal|
|identical protein binding|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.24|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.22|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.12|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.11|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.09|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.73|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.81|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.84|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.67|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tacc3|TACC3]]|0.408|
|[[:human genes:f:fkbpl|FKBPL]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2112
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRAP Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>