BRAP

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK626616 14μM R08 exp485	-2.24
Sulforaphane 9μM R08 exp525	-2.22
Sulforaphane 9μM R08 exp526 no dilution day6	-2.12
Etoposide 0.3μM R05 exp199	-2.11
Vincristine 0.0005μM R04 exp190	-2.09
MLN-4924 0.2μM R00 exp21	-1.73
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.81
RK-33 8μM R08 exp518	1.84
MK2206 4μM R08 exp504	2.67
Vemurafenib 6.6μM R08 exp434	2.94

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
TACC3	0.408
FKBPL	0.408

zf-UBP
BRAP2

nuclear localization sequence binding
ubiquitin ligase complex
nucleic acid binding
ubiquitin protein ligase activity
nuclear membrane
ubiquitin-protein transferase activity
Ras protein signal transduction
small GTPase mediated signal transduction
MAPK cascade
signal transduction by protein phosphorylation
protein ubiquitination
protein modification by small protein conjugation
zinc ion binding
protein phosphorylation
protein modification by small protein conjugation or removal
identical protein binding
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
intracellular signal transduction