BRE [The Human Chemical-Genetic Interaction Map Project]

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======= BRE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BABAM2
  * **<color #00a2e8>Official Name</color>**: BRISC and BRCA1 A complex member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9577|9577]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NXR7|Q9NXR7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610497|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BRE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear ubiquitin ligase complex|
|peroxisome targeting sequence binding|
|BRISC complex|
|BRCA1-A complex|
|signal transduction involved in G2 DNA damage checkpoint|
|G2 DNA damage checkpoint|
|polyubiquitin modification-dependent protein binding|
|tumor necrosis factor receptor binding|
|protein K63-linked deubiquitination|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|positive regulation of DNA repair|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of response to DNA damage stimulus|
|negative regulation of cell cycle G2/M phase transition|
|signal transduction in response to DNA damage|
|regulation of DNA repair|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|response to ionizing radiation|
|double-strand break repair|
|positive regulation of DNA metabolic process|
|cell cycle checkpoint|
|regulation of cell cycle G2/M phase transition|
|regulation of response to DNA damage stimulus|
|negative regulation of cell cycle phase transition|
|protein deubiquitination|
|protein modification by small protein removal|
|negative regulation of cell cycle process|
|regulation of DNA metabolic process|
|response to radiation|
|regulation of cell cycle phase transition|
|cell division|
|DNA repair|
|negative regulation of cell cycle|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|programmed cell death|
|chromosome organization|
|cell death|
|response to abiotic stimulus|
|regulation of cell cycle|
|proteolysis|
|cell cycle|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-3.38|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.25|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.22|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.12|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.03|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.83|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.81|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.72|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.79|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.99|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.1|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam175a|FAM175A]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6166
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRE Expression in NALM6 Cells: 3.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>