BRE

Entrez Summary: This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nuclear ubiquitin ligase complex
peroxisome targeting sequence binding
BRISC complex
BRCA1-A complex
signal transduction involved in G2 DNA damage checkpoint
G2 DNA damage checkpoint
polyubiquitin modification-dependent protein binding
tumor necrosis factor receptor binding
protein K63-linked deubiquitination
double-strand break repair via nonhomologous end joining
non-recombinational repair
positive regulation of DNA repair
signal transduction involved in DNA integrity checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in cell cycle checkpoint
positive regulation of response to DNA damage stimulus
negative regulation of cell cycle G2/M phase transition
signal transduction in response to DNA damage
regulation of DNA repair
DNA damage checkpoint
DNA integrity checkpoint
response to ionizing radiation
double-strand break repair
positive regulation of DNA metabolic process
cell cycle checkpoint
regulation of cell cycle G2/M phase transition
regulation of response to DNA damage stimulus
negative regulation of cell cycle phase transition
protein deubiquitination
protein modification by small protein removal
negative regulation of cell cycle process
regulation of DNA metabolic process
response to radiation
regulation of cell cycle phase transition
cell division
DNA repair
negative regulation of cell cycle
chromatin organization
regulation of cellular response to stress
DNA metabolic process