BRMS1 [The Human Chemical-Genetic Interaction Map Project]

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======= BRMS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRMS1
  * **<color #00a2e8>Official Name</color>**: BRMS1 transcriptional repressor and anoikis regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25855|25855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCU9|Q9HCU9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRMS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRMS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606259|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sds3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of anoikis|
|Sin3-type complex|
|positive regulation of protein deacetylation|
|regulation of anoikis|
|histone deacetylase activity|
|NF-kappaB binding|
|regulation of protein deacetylation|
|histone deacetylation|
|protein deacetylation|
|protein deacylation|
|macromolecule deacylation|
|negative regulation of NF-kappaB transcription factor activity|
|histone deacetylase binding|
|negative regulation of DNA-binding transcription factor activity|
|histone modification|
|covalent chromatin modification|
|regulation of DNA-binding transcription factor activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|chromatin organization|
|negative regulation of transcription by RNA polymerase II|
|apoptotic process|
|programmed cell death|
|chromosome organization|
|cell death|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.8|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.1|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.06|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.97|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.94|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.88|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.88|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.86|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.85|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.77|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.75|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.74|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.73|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.71|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.74|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.75|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.81|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.86|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.88|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.97|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.01|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.08|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.1|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.24|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.31|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.36|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.42|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.54|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.9|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.96|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.08|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.45|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3.58|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ing1|ING1]]|0.705|
|[[:human genes:s:sap130|SAP130]]|0.628|
|[[:human genes:a:arid4b|ARID4B]]|0.57|
|[[:human genes:s:suds3|SUDS3]]|0.528|
|[[:human genes:s:sin3a|SIN3A]]|0.508|
|[[:human genes:b:brd1|BRD1]]|0.475|
|[[:human genes:f:fam204a|FAM204A]]|0.449|
|[[:human genes:r:rbm26|RBM26]]|0.447|
|[[:human genes:h:hexim1|HEXIM1]]|0.422|
|[[:human genes:p:prim1|PRIM1]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3507
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRMS1 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>