BRMS1

Gene Information

Official Symbol: BRMS1
Official Name: BRMS1 transcriptional repressor and anoikis regulator
Aliases and Previous Symbols: N/A
Entrez ID: 25855
UniProt: Q9HCU9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.8
Artemisinin 50μM R08 exp450	-2.1
Wortmannin 5μM R00 exp38	-2.06
HMS-I1 10μM R06 exp256	-1.97
UMK57 1μM R01 exp59	-1.94
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.88
Pimelic-diphenylamide-106 5μM R00 exp28	-1.88
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.86
BML-284 0.09μM R08 exp460	-1.85
CI-1040 9.5μM R08 exp472	-1.77
DABN 20μM R00 exp17	-1.75
Clomiphene 4.4μM R02 exp68	-1.74
Taxol 0.002μM R01 exp54	-1.73
MLN-4924 2μM R00 exp22	-1.71
Phenformin 20μM R05 exp212	1.74
Latrunculin-B 10μM R07 exp374	1.75
Cytochalasin-B 5μM R07 exp349	1.81
LY2090314 0.003μM R08 exp500 no dilution day6	1.86
Cyclosporin-A 0.8μM R07 exp347	1.88
QNZ 0.01μM R05 exp241	1.97
Salubrinal 20μM R07 exp399	2.01
Pyridostatin 4μM R05 exp240	2.08
Doxycycline 10μM R00 exp18	2.1
Oligomycin-A 2μM R00 exp25	2.24
NMS-873 0.07μM R07 exp380	2.31
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.36
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2.42
Hypoxia 5%O2 R04 exp191	2.54
Deguelin 0.15μM R05 exp209	2.9
THZ531 0.225μM R08 exp444	2.96
Ethanol 0.01 R05 exp234	3.08
Lead acetate 2000μM R08 exp498 no dilution day6	3.45
Lead acetate 2000μM R08 exp497	3.58
ML-792 0.2μM R08 exp505	3.89

Gene	Correlation
ING1	0.705
SAP130	0.628
ARID4B	0.57
SUDS3	0.528
SIN3A	0.508
BRD1	0.475
FAM204A	0.449
RBM26	0.447
HEXIM1	0.422
PRIM1	0.422

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3507
Expression level (log2 read counts): 5.37

Expression Distribution

positive regulation of anoikis
Sin3-type complex
positive regulation of protein deacetylation
regulation of anoikis
histone deacetylase activity
NF-kappaB binding
regulation of protein deacetylation
histone deacetylation
protein deacetylation
protein deacylation
macromolecule deacylation
negative regulation of NF-kappaB transcription factor activity
histone deacetylase binding
negative regulation of DNA-binding transcription factor activity
histone modification
covalent chromatin modification
regulation of DNA-binding transcription factor activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
chromatin organization
negative regulation of transcription by RNA polymerase II
apoptotic process
programmed cell death
chromosome organization
cell death
negative regulation of molecular function
negative regulation of transcription, DNA-templated
positive regulation of protein modification process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
regulation of apoptotic process
negative regulation of biosynthetic process
regulation of programmed cell death
positive regulation of cellular protein metabolic process