BTBD9 [The Human Chemical-Genetic Interaction Map Project]

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======= BTBD9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BTBD9
  * **<color #00a2e8>Official Name</color>**: BTB domain containing 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114781|114781]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96Q07|Q96Q07]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BTBD9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BTBD9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611237|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BACK|
|F5 F8 type C|
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|circadian sleep/wake cycle, non-REM sleep|
|circadian sleep/wake cycle, sleep|
|circadian sleep/wake cycle process|
|circadian sleep/wake cycle|
|multicellular organismal iron ion homeostasis|
|serotonin metabolic process|
|primary amino compound metabolic process|
|sleep|
|regulation of synaptic vesicle endocytosis|
|sensory perception of temperature stimulus|
|circadian behavior|
|rhythmic behavior|
|indole-containing compound metabolic process|
|regulation of synaptic vesicle recycling|
|long-term memory|
|adult locomotory behavior|
|iron ion homeostasis|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|regulation of synaptic vesicle cycle|
|memory|
|transition metal ion homeostasis|
|circadian rhythm|
|adult behavior|
|ammonium ion metabolic process|
|locomotory behavior|
|regulation of endocytosis|
|learning or memory|
|rhythmic process|
|cognition|
|multicellular organismal homeostasis|
|regulation of neurotransmitter levels|
|organic hydroxy compound metabolic process|
|regulation of vesicle-mediated transport|
|behavior|
|metal ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|regulation of cellular localization|
|sensory perception|
|chemical homeostasis|
|nervous system process|
|homeostatic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.13|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.89|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.74|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.73|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.72|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.72|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.71|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.71|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.77|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.79|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.03|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2.1|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.26|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14334
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BTBD9 Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>