BTF3

Entrez Summary: N/A
UniProt Summary: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.85
Demecolcine 0.03μM R05 exp228	-1.8
Thimerosal 0.85μM R08 exp529	1.71
Bleomycin 5μM R08 exp459	2.18
Doxorubicin 0.02μM R08 exp478	2.6
Etoposide 0.1μM R05 exp198	2.61
Etoposide 0.3μM R05 exp199	2.68

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Gene	Correlation
TRIAP1	0.413
SLC25A26	0.404

nascent polypeptide-associated complex
polysomal ribosome
in utero embryonic development
transcription by RNA polymerase II
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
embryo development ending in birth or egg hatching
RNA biosynthetic process
embryo development
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
RNA binding
protein transport
peptide transport
amide transport
establishment of protein localization
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
nitrogen compound transport
gene expression