C10orf90

Entrez Summary: N/A
UniProt Summary: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.29
Vemurafenib 6.6μM R02 exp89	-2.19
BI-D1870 3.15μM R02 exp66	-1.92

alpha-actinin binding
regulation of centriole replication
regulation of centrosome duplication
regulation of centrosome cycle
centriole
protein stabilization
regulation of microtubule cytoskeleton organization
actin cytoskeleton
regulation of organelle assembly
ubiquitin protein ligase activity
regulation of microtubule-based process
regulation of protein stability
protein polyubiquitination
centrosome
regulation of cytoskeleton organization
protein ubiquitination
regulation of cell cycle process
protein modification by small protein conjugation
regulation of cellular component biogenesis
protein modification by small protein conjugation or removal
regulation of cell cycle
regulation of organelle organization