C12orf66 [The Human Chemical-Genetic Interaction Map Project]

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======= C12orf66 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C12orf66
  * **<color #00a2e8>Official Name</color>**: chromosome 12 open reading frame 66
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=144577|144577]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MD2|Q96MD2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C12orf66&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C12orf66|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2003|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|KICSTOR complex|
|negative regulation of TORC1 signaling|
|protein localization to lysosome|
|regulation of TORC1 signaling|
|cellular response to glucose starvation|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|negative regulation of TOR signaling|
|protein localization to vacuole|
|regulation of TOR signaling|
|cellular response to starvation|
|response to starvation|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|lysosomal membrane|
|cellular response to external stimulus|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|response to extracellular stimulus|
|protein localization to organelle|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|cellular response to stress|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.61|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-3.41|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.14|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.93|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.43|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.41|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.35|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.31|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.27|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.18|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.16|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.15|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.09|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.07|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.06|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.01|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.01|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.98|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.97|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.96|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.94|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.91|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.88|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.87|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.85|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.85|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.83|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.81|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.76|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.73|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.73|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.72|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.7|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.77|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.78|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.78|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.8|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.9|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.05|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.09|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.16|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.38|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.41|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|3.55|
|[[:results:exp504|MK2206 4μM R08 exp504]]|4.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:szt2|SZT2]]|0.746|
|[[:human genes:k:kptn|KPTN]]|0.733|
|[[:human genes:n:nprl3|NPRL3]]|0.713|
|[[:human genes:i:itfg2|ITFG2]]|0.709|
|[[:human genes:n:nprl2|NPRL2]]|0.691|
|[[:human genes:d:depdc5|DEPDC5]]|0.65|
|[[:human genes:s:sesn2|SESN2]]|0.564|
|[[:human genes:t:tsc2|TSC2]]|0.543|
|[[:human genes:t:tsc1|TSC1]]|0.517|
|[[:human genes:c:ccdc130|CCDC130]]|0.485|
|[[:human genes:p:pds5b|PDS5B]]|0.432|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18272
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C12orf66 Expression in NALM6 Cells: 7.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>