C12orf66
Gene Information
- Official Symbol: C12orf66
- Official Name: chromosome 12 open reading frame 66
- Aliases and Previous Symbols: N/A
- Entrez ID: 144577
- UniProt: Q96MD2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000269|PubMed:28199306}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18272
- Expression level (log2 read counts): 3.59
C12orf66 Expression in NALM6 Cells: 7.71
