C18orf32 [The Human Chemical-Genetic Interaction Map Project]

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======= C18orf32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C18orf32
  * **<color #00a2e8>Official Name</color>**: chromosome 18 open reading frame 32
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=497661|497661]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCD1|Q8TCD1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C18orf32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C18orf32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619979|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May activate the NF-kappa-B signaling pathway. {ECO:0000269|PubMed:12761501}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of intracellular signal transduction|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.78|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.57|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.42|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.4|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.38|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.3|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.15|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.09|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.03|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.02|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.97|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.95|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.94|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.87|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.75|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.73|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.71|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.7|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.72|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.73|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.73|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.74|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.78|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.8|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.83|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.89|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.91|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.93|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.96|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.97|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.03|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.04|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2.23|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.26|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.41|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.41|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.41|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.42|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.43|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.6|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.62|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.98|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.03|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|3.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7915
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C18orf32 Expression in NALM6 Cells: 8.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>