C18orf32

Entrez Summary: N/A
UniProt Summary: May activate the NF-kappa-B signaling pathway. {ECO:0000269|PubMed:12761501}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.78
Cannabidiol 20μM R08 exp466	-2.57
Etoposide 0.1μM R05 exp198	-2.42
Sulforaphane 9μM R08 exp525	-2.4
Vinblastine 0.015μM R05 exp208	-2.38
Cannabidiol 13μM R08 exp465	-2.3
Thapsigargin 0.005μM R07 exp407	-2.15
CB-5083 0.4μM R08 exp468	-2.09
Milciclib 2μM R08 exp502	-2.03
Hydroxyurea 100μM R07 exp329	-2.02
Cyclosporin-A 0.8μM R07 exp347	-1.97
MK2206 4μM R08 exp504	-1.95
ML-792 0.2μM R08 exp505	-1.94
Pimelic-diphenylamide-106 5μM R00 exp28	-1.87
AICAR 240μM R05 exp211	-1.75
Vemurafenib 6.6μM R02 exp89	-1.73
Methotrexate 0.01μM R08 exp501	-1.71
Chloramphenicol 2μM R00 exp12	1.7
PNU96415E 10μM R03 exp145	1.72
GSK-J4 1-1.25μM to day4 R07 exp363	1.73
Rapamycin 1μM R00 exp29	1.73
2-Deoxy-D-glucose 800μM R05 exp214	1.74
CoCl2 18μM R07 exp346	1.78
2-Methoxyestradiol 0.55μM R07 exp310	1.8
Vinblastine 0.002μM R01 exp60	1.83
Cycloheximide 0.2μM R00 exp15	1.89
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.91
ZLN024 50μM R08 exp538	1.93
Prochlorperazine 5.2μM R02 exp77	1.96
Etoposide 1μM R00 exp19	1.97
Rifampicin 10μM R00 exp32	2.03
Actinomycin-D 0.01μM R00 exp4	2.04
UNC2400 2μM R03 exp156	2.23
5-Fluorouracil 2μM R00 exp1	2.26
ABT-702 0.1μM R06 exp260	2.41
CCCP 1μM R00 exp11	2.41
Daidzin 10μM R06 exp280	2.41
Rotenone 20μM R00 exp34	2.42
5-Fluorouracil 20μM R00 exp2	2.43
ABT-702 5μM R07 exp318	2.6
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	2.62
Oligomycin-A 2μM R00 exp25	2.98
Aminopterin 0.005μM R07 exp335	3.03
Q15 1 to 2μM on day4 R04 exp164	3.47

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of intracellular signal transduction
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction