C19orf43 [The Human Chemical-Genetic Interaction Map Project]

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======= C19orf43 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIR
  * **<color #00a2e8>Official Name</color>**: telomerase RNA component interacting RNase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79002|79002]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQ61|Q9BQ61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C19orf43&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C19orf43|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621422|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335). {ECO:0000269|PubMed:28322335}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|5-3 exonuclease activity|
|3-5 exonuclease activity|
|rRNA catabolic process|
|ncRNA catabolic process|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|RNA phosphodiester bond hydrolysis|
|rRNA metabolic process|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA binding|
|RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.74|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.71|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.74|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.79|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.84|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.94|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.96|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.01|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.04|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.05|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.06|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.12|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.12|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.26|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.32|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.38|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.39|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.49|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.51|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.75|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.77|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.15|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.409|
|[[:human genes:t:trrap|TRRAP]]|0.403|
|[[:human genes:r:rrm1|RRM1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1209
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C19ORF43 Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>