C19orf43

Entrez Summary: N/A
UniProt Summary: Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335). {ECO:0000269|PubMed:28322335}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 10μM R00 exp20	-1.74
All-trans-Retinoic-Acid 8μM R07 exp333	1.71
GSK-J4 1μM R07 exp362	1.74
2-Methoxyestradiol 0.55μM R07 exp310	1.79
BN82002 4μM R07 exp340	1.84
Olaparib 4μM R08 exp512	1.94
Bafilomycin-A1 0.009μM R08 exp454	1.96
Golgicide-A 4μM R03 exp122	2.01
Colchicine 0.009μM R05 exp215	2.04
TRAIL 5ng/ml R00 exp35	2.05
Resveratrol 16μM R03 exp147	2.06
GSK-J4 1-1.25μM to day4 R07 exp363	2.12
Quercetin 20μM R08 exp517	2.12
BML-284 0.09μM R08 exp460	2.26
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.32
Cryptotanshinone 12μM R05 exp227	2.38
UMK57 1μM R01 exp59	2.39
UM0131023 0.05μM R05 exp248	2.49
Genistein 15μM R07 exp360	2.51
GSK626616 14μM R08 exp485	2.75
Artemisinin 50μM R08 exp450	2.77
Tubacin 1.6μM R07 exp416	3.15
Nutlin-3A 1.6μM R06 exp294	3.78

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

5-3 exonuclease activity
3-5 exonuclease activity
rRNA catabolic process
ncRNA catabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
RNA phosphodiester bond hydrolysis
rRNA metabolic process
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ncRNA metabolic process
organic cyclic compound catabolic process
cellular macromolecule catabolic process
macromolecule catabolic process
RNA binding
RNA metabolic process
organic substance catabolic process
cellular catabolic process