C19orf52

Entrez Summary: N/A
UniProt Summary: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40. {ECO:0000269|PubMed:27554484, ECO:0000269|PubMed:27718247}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 32/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	3/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	6/75
lymphocyte	1/16
ovary	2/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TIM22 mitochondrial import inner membrane insertion complex
protein insertion into mitochondrial inner membrane
establishment of protein localization to mitochondrial membrane
protein insertion into mitochondrial membrane
protein insertion into membrane
inner mitochondrial membrane organization
protein targeting to mitochondrion
establishment of protein localization to mitochondrion
mitochondrial intermembrane space
protein localization to mitochondrion
mitochondrial membrane organization
mitochondrial transport
establishment of protein localization to membrane
protein targeting
mitochondrial inner membrane
establishment of protein localization to organelle
mitochondrion organization
protein localization to membrane
protein localization to organelle
membrane organization
intracellular protein transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport