C2orf47

Entrez Summary: N/A
UniProt Summary: Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation (PubMed:27642048). Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048). {ECO:0000269|PubMed:27642048}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein insertion into membrane from inner side
protein insertion into mitochondrial inner membrane from matrix
calcium import into the mitochondrion
protein insertion into mitochondrial inner membrane
establishment of protein localization to mitochondrial membrane
protein insertion into mitochondrial membrane
mitochondrial calcium ion transmembrane transport
mitochondrial calcium ion homeostasis
protein insertion into membrane
calcium ion import
inner mitochondrial membrane organization
ribosome binding
protein targeting to mitochondrion
establishment of protein localization to mitochondrion
protein localization to mitochondrion
cytosolic calcium ion transport
mitochondrial transmembrane transport
mitochondrial membrane organization
calcium ion transmembrane transport
mitochondrial transport
calcium ion transport
establishment of protein localization to membrane
divalent metal ion transport
divalent inorganic cation transport
protein targeting
mitochondrial matrix
mitochondrial inner membrane
establishment of protein localization to organelle
cellular calcium ion homeostasis
mitochondrion organization
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
protein localization to membrane
divalent inorganic cation homeostasis
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport