C3orf58

Entrez Summary: N/A
UniProt Summary: May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade. {ECO:0000269|PubMed:23784961}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of smooth muscle cell apoptotic process
cardiac muscle cell proliferation
COPI vesicle coat
striated muscle cell proliferation
muscle cell proliferation
regulation of smooth muscle cell apoptotic process
cardiac muscle tissue growth
heart growth
negative regulation of muscle cell apoptotic process
regulation of muscle cell apoptotic process
organ growth
regulation of phosphatidylinositol 3-kinase signaling
cardiac muscle tissue development
striated muscle tissue development
muscle tissue development
developmental growth
growth
heart development
cell population proliferation
Golgi membrane
circulatory system development
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
regulation of apoptotic process
regulation of programmed cell death
extracellular space
regulation of cell death
tissue development
regulation of intracellular signal transduction